Medical/Research/Watch

Signs of Aging Delayed

An exciting new mouse study performed by researchers at the Mayo Clinic may provide hope for delaying signs of aging and aging related discomforts and disease in the future.

Cells normally produce additional cells throughout their life cycle. Senescent cells, also called deadbeat cells, are cells that are still alive but are no longer multiplying. Senescent cells produce factors that harm the nearby cells, and as a result cause tissue inflammation.

Alcoholism Vaccine Study

By focusing on a group of enzymes that normally are activated to break down alcohol in our bodies, a
group of researchers from Chile have developed a vaccine to help alcoholics recover from their
disease.

The enzymes, aldehyde dehydrogenase, are disabled within the vaccine, creating the sensation of a
hangover within just a few drinks, discouraging consumption. Lead researcher Juan Asenio, from
Chile’s Faculty of Sciences and Mathematics, states that the desire to consume alcohol once on the

Alzheimer’s and Green Tea

Green tea may be more than just a tasty, warm drink. It may help you protect yourself from dementia
and Alzheimer’s according to a study from the researchers at the Medicinal Plant Research Group from
Newcastle University in collaboration with the Scottish Crop Research Institute.

Originally published in the journal Phytomedicine, the study reveals that polyphenols in green tea
may improve cognitive skills. Two compounds, hydrogen peroxide and beta-amyloid, have important

Artificial Pancreas Guidelines

Biomedical device makers are currently designing artificial pancreases for the treatment of diabetes type 1 while the FDA has drafted guidance to provide phase guidelines.

Although not a cure for diabetes type 1, an artificial pancreas could lead to a significant improvement in the quality of life and outcome for these patients. An artificial pancreas consists of an insulin pump and a continuous glucose monitor.

Bariatric Surgery and Bone Health

A study presented at the Endocrine Society’s 93rd Annual Meeting identified that patients who undergo bariatric surgery are at greater risk of bone fracture than previously thought.

Kelly Nakamura was the lead author of the study. He is a Mayo Clinic College of Medicine medical student. The principal investigator was Kurt Kennel, MD, an assistant professor of medicine in the endocrinology division at Mayo.

Chronic Pain Relief

About 30 million American suffer from moderate to severe chronic pain that is not associated with cancer, according to the American Pain Society. Now, researchers at the University of California at Davis have discovered data that may provide a way in the future to develop new approaches to understand and manage that pain.

Dirty Apples

Apples have risen to the top of the Dirty Dozen list, with an estimated 98% of apples tested having pesticide residue according to the Environmental Working Group researchers. Data from the USDA and the FDA from years 2000-2009 were analyzed.

The Dirty Dozen list is a yearly survey compiled by the USDA and represents produce with the highest pesticide burden. This year’s list includes apples, celery, strawberries, peaches, spinach, blueberries, imported grapes and nectarines, sweet bell peppers, potatoes, lettuce, and kale.

Eat Your Fruit and Veggies!

Researchers from the Karolinska Institute in Sweden have reported a new study in the journal Stroke regarding the importance of fruits and vegetables. The study shows that even for women who have a history of cardiovascular disease, consuming more fruits and vegetables lowers the risk of stroke.

The team identified 31,035 women free of cardiovascular disease and 5,680 others with a history of it from two counties, aged 49-83 years of age.

Four Genes and ADHD

Researchers from the Center for Applied Genomics at The Children’s Hospital of Philadelphia have reported new study findings regarding ADHD and four gene variants in the journal Nature Genetics.

In the study 1000 ADHD children were compared with 4100 children of the same age without ADHD.  Whole-genome analyses was performed on all of the children.

Frog Skin and the Impact on Cancer

An interesting study performed by Professor Chris Shaw and his colleagues at Queen’s University Belfast has unveiled that two proteins found in the secretions of frog skin can disrupt the growth of blood vessels.

Future Lung Regeneration

Weill Cornell Medical College investigators have reported in the journal Cell that they have made an important discovery about the process of “turning on” lung regeneration.

Scientists have known for some time that mice may be able to regenerate and expand one lung if the other is missing, but now they have more information about the molecular triggers behind this.

Gene Therapy for Eye Disease

 

A new study performed by Tufts University School of Medicine and the Sackler School of Graduate Biomedical Sciences focused on non-viral gene therapy and eye disease, with promising results.

The study was published in the online version of Molecular Therapy. Senior author Rajendra Kumar-Singh said, “The most common approach to gene therapy involves using a virus to deliver DNA to cells.” Because viruses can also prompt non-desired immune responses, non-viral gene therapy is safer, however until now there have been barriers.

GlcNAc Uses Promising

GlcNAc, otherwise known as N-acetylglucosamine, shows promise in studies for being able to combat some of the effects of MS and other diseases. One study, published online in The Journal of Biological Chemistry, focused on research performed by researchers at UC Irvine.

The supplement is more effective than and similar to glucosamine. In MS patients, central nervous system tissues that normally protect and insulate nerves are attacked by and broken down by abnormal T-cells that tell the immune system to do so. In the study, these actions were inhibited.

Guilt and Pain Study

A study published in Psychological Science and carried out by psychological scientist Brock Bastian of the University of Queensland, Australia explores bodily pain and psychological consequences.

Hepatitis C Vaccine Study

Hepatitis C, a chronic liver disease, is the target of an experimental vaccine in the first phases of human clinical trials in the UK.

The study findings were published online in the January 4th issue of Science Translational Medicine by researchers at the University of Oxford. Results are promising for the disease, which currently has no vaccine and infects approximately 170 million people globally.

Hope for Quadriplegics

A study published in the journal Nature showcases the findings from research scientists at Duke University Center of Neuroengineering focusing on technology that could change lives of quadriplegics in the future.

In the study, brain-machine-brain interfaces (BMBI) were used with two monkeys to determine if the monkeys could move the virtual hands of an avatar to move virtual objects and detect differences in textures.

Khat Increased Risk of Stroke and Heart Attack

Khat, a natural stimulant recently spreading throughout Western Europe and the U.S. can cause increased stroke and heart attack incidence for those with heart disease according to a new study published in Circulation: Journal of the American Heart Association.

Chewed by East Africans and Arabians for centuries, the Catha edulis plant can produce effects similar to amphetamines and cocaine. Known today as khat, these effects include euphoria, weight loss, lack of appetite, and hyperactivity.

Longer Lasting Insulin

Millions of Americans have diabetes, with more diagnosed every day. There is a new study that shows that an alternate form of insulin may be possible in the future that allows diabetics to inject less often while maintaining adequately controlled blood glucose levels.

Moderate Drinking and Dementia

Studies for some time have shown there may be a benefit to moderate drinking, particularly of wine as wine has resveratrol. It is important, however to find the balance as over-consumption of alcohol can actually statistically raise the risk of dementia.

New Study Inspired Hope for Ovarian Cancer

A new study published in online journal Gynecologic Oncology shows that the combination of certain drugs may prove beneficial against ovarian cancer cells.

Late stage ovarian cancer cells can become resistant to chemotherapy compounds, and the result is often fatal. Scientists from the Mayo Clinic in Florida have focused on the resistance of those cells in their new study, with promising results.

NSAIDs and Heart Attack Risk

Researchers working on an international study from the UK and Canada have linked non-steroidal, anti-inflammatory drugs (NSAIDs) to an increased risk of heart attacks and strokes. The study, published in the journal PLoS Medicine, showed the findings from the research team’s systematic review of 51 large scale studies of NSAIDs in the US, Canada, Europe and Australia.

Painkiller Overdose Rate

A new CDC Vital Signs report indicates that narcotic painkillers such as oxymorphone, oxycodone, methadone, and hydrocodone are killing more than 40 people every day in the U.S. due to overdose. In fact, more Americans die annually from prescription painkiller overdose than those who overdose on cocaine or heroin combined, according to the report.

The National Survey on Drug Use and Health, USA indicates that in 2010 approximately 1 in 20 individuals over the age of 12 state they are using prescription painkillers for recreational purposes. That is a total of 12 million people.

Parkinson’s Disease Link to Immune System Genes

 

A team from the New York Department of Public Health has discovered that genes within the immune system are linked to Parkinson’s Disease. The NeuroGenetics Research Consortium, which led the study, published the work in the online version of Nature Genetics.

Patient Specific Therapies

Stem cell therapies may be able to be more targeted to individualized patients to combat chronic or life-threatening diseases in the future. A study published in the journal Nature by scientists at NYSCF and Columbia University focuses on embryonic stem cells derived from patients.

Sterile Mosquitoes Fight Dengue Fever

Dengue fever can develop into a lethal situation for people and is spread by mosquitoes carrying the viral infection. It is estimated that between 50-100 million new cases occur each year.

Scientists working on a new study published in Nature Biotechnology are looking at ways to reduce the numbers of mosquitoes carrying and infecting people with Dengue Fever. To do so they have introduced a genetically sterile mosquito into the wild (during clinical studies), hoping that the population will be reduced as a result.

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